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Research

Esipova, Tatiana

Title/s:  Assistant Professor

Office #:  FH-203

Phone: 773.508.3357

Email: tesipova@luc.edu

Degrees

  • 2007 Ph.D. in Organic Chemistry, M.V. Lomonosov Moscow State University, Russia
  • 2007-2008 Postdoctoral Researcher, Swiss Federal Institute of Technology, Lausanne (EPFL), Switzerland
  • 2009-2014 Postdoctoral Researcher, University of Pennsylvania, USA
  • 2014-2017 Research Scientist, University of Pennsylvania, USA

Research Interests

We are a multidisciplinary research group, working at the intersection of synthetic organic chemistry, biochemistry, photophysics, nanotechnology and biomedical imaging. Our main focus is the development of optical probes for visualizing and quantifying physiological processes occurring in the brain in health and disease. We use methods of synthetic chemistry and biochemistry to design and construct optical sensors for real-time monitoring and quantification of neurotransmitters and small ions in vivo. These probes aim to uncover the mechanisms of interneuronal communication and information transmission in the brain on the molecular level.

Students in our group will have an opportunity to work in highly collaborative multidisciplinary environment, and will receive broad training in synthetic organic chemistry, biochemistry, photophysics, nanotechnology and biomedical imaging.

Selected Publications

  • Esipova, T. V., Rivera-Jacquez, H. J., Weber, B., Masunov, A. E., Vinogradov, S. A. "Stabilizing g-States in Centrosymmetric Tetrapyrroles: Two-Photon-Absorbing Porphyrins with Bright Phosphorescence" J. Phys. Chem. A, 2017, 121(33), 6243-6255. doi: 10.1021/acs.jpca.7b04333.

  • Esipova, T. V., Rivera-Jacquez, H. J., Weber, B., Masunov, A. E., Vinogradov, S. A. “Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π-Extension and Peripheral Substitution.” J. Am. Chem. Soc., 2016, 138(48), 15648-15662. doi: 10.1021/jacs.6b09157

  • Esipova, T. V., Vinogradov, S. A. "Synthesis of Phosphorescent Asymmetrically π-Extended Porphyrins for Two-Photon Applications." J. Org. Chem., 2014, 79(18), 8812-8825. doi: 10.1021/jo501521x

  • Esipova, T. V., Ye, X., Collins, J. E., Sakadžić, S., Mandeville, E. T., Murray, C. B., Vinogradov, S. A. "Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources."  Proc. Natl. Acad. Sci. U. S. A., 2012, 109(51), 20826-20831.doi:10.1073/pnas.1213291110

  • Esipova, T. V., Karagodov, A., Miller, J., Wilson, D. F., Busch, T. M., Vinogradov, S. A. "Two New "Protected" Oxyphors for Biological Oximetry: Properties and Application in Tumor Imaging."  Anal. Chem., 2011, 83 (22), 8756-8765. doi:10.1021/ac2022234.